EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.2.1.48 | Homo sapiens | - |
- |
- |
3.2.1.48 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.2.1.48 | Caco-2 cell | - |
Homo sapiens | - |
3.2.1.48 | HT-29 cell | - |
Homo sapiens | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.2.1.48 | sucrase isomaltase | - |
Mus musculus |
3.2.1.48 | sucrase isomaltase | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.2.1.48 | physiological function | core2 1,6-N-acetylglucosaminyltransferase-2 knockdown significantly reduces cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV in Caco-2 cells. Overexpression of the core3 structure in HT-29 cells attenuates cell surface expression of both enzymes | Homo sapiens |
3.2.1.48 | physiological function | the fully glycosylated mature form of sucrase isomaltase is decreased in core2 1,6-N-acetylglucosaminyltransferase-2 knock-out mice but not in core2 N-acetylglucosaminyltransferase-3 nulls. Expression of sucrase isomaltase and dipeptidyl peptidase-IV is dramatically reduced in core2 1,6-N-acetylglucosaminyltransferase-1-3 triple knock-out mice. Goblet cells in the upper part of the crypt show impaired maturation in the core2 O-glycan-deficient mice | Mus musculus |